USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: Q8WXA6 USC-OGP 2-DE database:  Q8WXA6 Q8WXA6 General information about the entry View entry in simple text format Entry name Q8WXA6 Primary accession number Q8WXA6 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Kinetochore scaffold 1; AltName: Full=ALL1-fused gene from chromosome 15q14 protein; Short=AF15q14; AltName: Full=Bub-linking kinetochore protein; Short=Blinkin; AltName: Full=Cancer susceptibility candidate gene 5 protein; AltName: Full=Cancer/testis antigen 29; Short=CT29; AltName: Full=Kinetochore-null protein 1; AltName: Full=Protein CASC5; AltName: Full=Protein D40/AF15q14;. Gene name Name=KNL1 {ECO:0000312|HGNC:HGNC:24054} Synonyms=CASC5, KIAA1570 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1285: pI=5.42; Mw=25688 Cross-references UniProtKB/Swiss-Prot Q8NG31; KNL1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name KNL1_HUMAN Primary accession number Q8NG31 Secondary accession number(s) Q8NHE1 Q8WXA6 Q9HCK2 Q9NR92 Sequence was last modified on  February 10, 2009 (version 3) Annotations were last modified on  March 15, 2017 (version 126) Name and origin of the protein Description RecName: Full=Kinetochore scaffold 1; AltName: Full=ALL1-fused gene from chromosome 15q14 protein; Short=AF15q14; AltName: Full=Bub-linking kinetochore protein; Short=Blinkin; AltName: Full=Cancer susceptibility candidate gene 5 protein; AltName: Full=Cancer/testis antigen 29; Short=CT29; AltName: Full=Kinetochore-null protein 1; AltName: Full=Protein CASC5; AltName: Full=Protein D40/AF15q14; Gene name Name=KNL1 {ECO:0000312|HGNC:HGNC:24054} Synonyms=CASC5, KIAA1570 Encoded on Name=KNL1 {ECO:0000312|HGNC:HGNC:24054}; Synonyms=CASC5, KIAA1570 Keywords 3D-structure; Alternative splicing; Cell cycle; Cell division; Centromere; Chromosomal rearrangement; Chromosome; Chromosome partition; Coiled coil; Complete proteome; Disease mutation; Kinetochore; Mental retardation; Mitosis; Nucleus; Phosphoprotein; Polymorphism; Primary microcephaly; Reference proteome; Repeat. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AF248041; AAF97513.1; -; mRNA EMBL AF461041; AAL67803.1; -; mRNA EMBL AB022190; BAC05691.1; -; mRNA EMBL AF173994; AAM45143.1; -; mRNA EMBL AC022405; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AB046790; BAB13396.1; -; mRNA CCDS CCDS42023.1; -. [Q8NG31-1]; . CCDS CCDS42024.1; -. [Q8NG31-2]; . RefSeq NP_653091.3; NM_144508.4. [Q8NG31-2]; . RefSeq NP_733468.3; NM_170589.4. [Q8NG31-1]; . UniGene Hs.181855; -; . PDB 3SI5; X-ray; 2.20 A; X/Y=234-252 PDB 4A1G; X-ray; 2.60 A; E/F/G/H=176-226 PDB 4NF9; X-ray; 2.80 A; A/B=2117-2337 PDB 4NFA; X-ray; 2.50 A; A=2131-2337 PDBsum 3SI5; -; . PDBsum 4A1G; -; . PDBsum 4NF9; -; . PDBsum 4NFA; -; . ProteinModelPortal Q8NG31; -; . SMR Q8NG31; -; . BioGrid 121354; 46; . DIP DIP-36474N; -; . IntAct Q8NG31; 42; . MINT MINT-1194225; -; . STRING 9606.ENSP00000335463; -; . iPTMnet Q8NG31; -; . PhosphoSitePlus Q8NG31; -; . DMDM 223590239; -; . EPD Q8NG31; -; . MaxQB Q8NG31; -; . PaxDb Q8NG31; -; . PeptideAtlas Q8NG31; -; . PRIDE Q8NG31; -; . DNASU 57082; -; . Ensembl ENST00000346991; ENSP00000335463; ENSG00000137812. [Q8NG31-1]; . Ensembl ENST00000399668; ENSP00000382576; ENSG00000137812. [Q8NG31-2]; . GeneID 57082; -; . KEGG hsa:57082; -; . UCSC uc010bbs.2; human. [Q8NG31-1]; . CTD 57082; -; . DisGeNET 57082; -; . GeneCards KNL1; -; . GeneReviews CASC5; -; . HGNC HGNC:24054; KNL1; . HPA HPA026624; -; . HPA HPA049647; -; . MalaCards KNL1; -; . MIM 604321; phenotype; . MIM 609173; gene; . neXtProt NX_Q8NG31; -; . OpenTargets ENSG00000137812; -; . Orphanet 2512; Autosomal recessive primary microcephaly; . PharmGKB PA142672201; -; . eggNOG ENOG410IF9C; Eukaryota; . eggNOG ENOG410XZXJ; LUCA; . GeneTree ENSGT00410000025918; -; . HOGENOM HOG000246954; -; . HOVERGEN HBG080986; -; . InParanoid Q8NG31; -; . KO K11542; -; . OMA MEITRSH; -; . OrthoDB EOG091G0YZU; -; . PhylomeDB Q8NG31; -; . TreeFam TF335517; -; . Reactome R-HSA-2467813; Separation of Sister Chromatids; . Reactome R-HSA-2500257; Resolution of Sister Chromatid Cohesion; . Reactome R-HSA-5663220; RHO GTPases Activate Formins; . Reactome R-HSA-606279; Deposition of new CENPA-containing nucleosomes at the centromere; . Reactome R-HSA-68877; Mitotic Prometaphase; . SIGNOR Q8NG31; -; . ChiTaRS CASC5; human; . EvolutionaryTrace Q8NG31; -; . GeneWiki CASC5; -; . GenomeRNAi 57082; -; . PRO PR:Q8NG31; -; . Proteomes UP000005640; Chromosome 15; . Bgee ENSG00000137812; -; . CleanEx HS_CASC5; -; . ExpressionAtlas Q8NG31; baseline and differential; . Genevisible Q8NG31; HS; . GO GO:0001669; C:acrosomal vesicle; IDA:UniProtKB; . GO GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0016604; C:nuclear body; IDA:HPA; . GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0001675; P:acrosome assembly; NAS:UniProtKB; . GO GO:0008608; P:attachment of spindle microtubules to kinetochore; IDA:UniProtKB; . GO GO:0051301; P:cell division; IEA:UniProtKB-KW; . GO GO:0034080; P:CENP-A containing nucleosome assembly; TAS:Reactome; . GO GO:0007067; P:mitotic nuclear division; IEA:UniProtKB-KW; . GO GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB; . GO GO:0034501; P:protein localization to kinetochore; IDA:MGI; . GO GO:0007062; P:sister chromatid cohesion; TAS:Reactome; . GO GO:0071173; P:spindle assembly checkpoint; IDA:UniProtKB; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
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• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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